Hidehisa Shimizu Selected Research

Indican

5/2014	Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
7/2013	Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.
4/2013	CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells.
3/2013	Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB.
2/2013	Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells.
1/2013	Indoxyl sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation.
9/2012	Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.
4/2012	Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells.
1/2012	Indoxyl sulfate induces nephrovascular senescence.
1/2012	AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats.

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Hidehisa Shimizu Research Topics

Disease

12	Chronic Renal Insufficiency 05/2014 - 01/2010
7	Fibrosis (Cirrhosis) 05/2014 - 11/2010
4	Obesity 12/2020 - 01/2010
4	Atherosclerosis 01/2013 - 01/2005
3	Body Weight (Weight, Body) 06/2020 - 01/2012
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2013 - 01/2010
3	Chronic Kidney Failure (Chronic Renal Failure) 11/2011 - 08/2009
2	Insulin Resistance 12/2014 - 02/2005
1	Dysbiosis 12/2020
1	Noncommunicable Diseases 07/2019
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019
1	Hypertension (High Blood Pressure) 03/2013
1	Anemia 01/2013
1	Arteriosclerosis 09/2012
1	Inflammation (Inflammations) 01/2012
1	Genomic Instability 04/2011
1	Infections 03/2009
1	Type 2 Diabetes Mellitus (MODY) 02/2005

Drug/Important Bio-Agent (IBA)

16	IndicanIBA 05/2014 - 08/2009
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2010
4	GalactosidasesIBA 01/2012 - 11/2010
3	Bile Acids and Salts (Bile Acids)IBA 12/2020 - 01/2014
3	AST 120IBA 05/2014 - 11/2010
2	Cholic AcidIBA 12/2020 - 07/2019
2	Deoxycholic Acid (Sodium Deoxycholate)IBA 07/2019 - 01/2014
2	Glucose (Dextrose)FDA LinkGeneric 12/2014 - 01/2005
1	Alanine Transaminase (SGPT)IBA 06/2020
1	CholesterolIBA 06/2020
1	Triglycerides (Triacylglycerol)IBA 06/2020
1	choloylglycine hydrolaseIBA 07/2019
1	AcidsIBA 07/2019
1	muricholic acidIBA 07/2019
1	Taurodeoxycholic AcidIBA 07/2019
1	Taurocholic Acid (Sodium Taurocholate)IBA 07/2019
1	Taurochenodeoxycholic AcidIBA 07/2019
1	difructose anhydride III (DFA III)IBA 07/2019
1	Volatile Fatty AcidsIBA 07/2019
1	ursodoxicoltaurineIBA 07/2019
1	LipidsIBA 12/2014
1	ReninIBA 05/2014
1	Prorenin ReceptorIBA 05/2014
1	AngiotensinogenIBA 04/2013
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 02/2013
1	tricarbonyldichlororuthenium (II) dimerIBA 01/2013
1	Erythropoietin FDA Link 01/2013
1	Carbon MonoxideIBA 01/2013
1	Small Interfering RNA (siRNA)IBA 01/2012
1	beta-Galactosidase (Lactaid)IBA 01/2012
1	Tyrosine (L-Tyrosine)FDA Link 01/2012
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2012
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2012
1	Retinoblastoma ProteinIBA 01/2012
1	Hepatocyte Nuclear FactorsIBA 04/2011
1	Sp1 Transcription FactorIBA 04/2011
1	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2011
1	Uremic ToxinsIBA 11/2010
1	Biological ProductsIBA 11/2010
1	Messenger RNA (mRNA)IBA 01/2010
1	CortactinIBA 03/2009
1	Peptide Hydrolases (Proteases)FDA Link 03/2009
1	Non-Receptor Type 2 Protein Tyrosine PhosphataseIBA 03/2009
1	Caspase 3 (Caspase-3)IBA 03/2009
1	Insulin ReceptorIBA 02/2005
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 02/2005

Therapy/Procedure

1	Nephrectomy 01/2012